Scalp microbiome regulation, slowing hair loss, improving hair health and hair density, promoting Wnt/β-catenin signaling.
Alopecia is a common disorder caused by the miniaturization of hair follicles, leading to the softening of hair. The most common type of hair loss is androgenetic alopecia, which accounts for 90% of cases, with 28% of men aged 18-29 and 53% of men over 40 being affected by this condition. From a pathophysiological perspective, the causes of alopecia are multifactorial, including stress, nutrition, exposome, genetic predisposition, and hormonal sensitivity.
The scalp microbiome has a significant relationship with hair growth disorders. Finding the optimal balance of both bacterial and fungal communities in hair is a step towards maintaining healthy hair. GREENTECH has developed anti-hair loss ingredients aimed at normalizing the scalp microbiome and regenerating follicular cells, focusing on the Wnt pathway, which plays a key role in the hair follicle and hair growth cycle.
In Vitro
1) Inhibition of key signaling pathways for hair growth:
- DDK-1 inhibition: 89%
- TGFβ1 inhibition: 55%
- sFRP-1 inhibition: 21%
- Endothelin-1 inhibition: 21%
2) Increased proliferation of dermal papilla cells: 41% increase (better than minoxidil)
3) Adjustment of the microbiome
In Vivo
Hair density: 28.5% improvement